BIOANALYTICAL SERVICES

Bioassays

As an innovation-driven contract research, development and manufacturing organization, Scorpius can support a wide variety of bioassays to evaluate your product’s safety, efficacy, potency, and purity. Our brand new biologics manufacturing facility in San Antonio, Texas is equipped with a 2,000 square-foot analytical testing lab, ideal for developing any assays that may be required for both the clinical and pre-clinical phases of development.

Our team has extensive experience developing and optimizing a range of assays for analysis and testing, including cell-based assays, molecular assays, and a full complement of immunoassays. Whether the desired analysis is quantitative, qualitative, or semiquantitative, Scorpius' design capabilities can be tailored to meet both client and regulatory requirements in a phase-appropriate manner, giving you the assay support you need from discovery to validation.

TECHNOLOGY

State-of-the-Art Equipment

Explore the instrumentation and equipment technology that can power your project forward.

OUR TECHNOLOGIES

CELL-BASED ASSAYS

Scorpius can support adapted or customized cellular assays to fully characterize or evaluate the efficacy and safety of your therapeutic product. Cell-based assays offer a relevant representation of a real-life model that can evaluate a variety of functional and biochemical effects. This enables the tracking of a number of variables, such as:

Number of cells or their behavior
Cell proliferation
Apoptosis
Signal transduction
Enzyme activity
Reporter gene activity
Antibody- (ADCC) and complement-dependent cytotoxicity (CDC)
Neutralizing antibodies (NAb)

Our team has developed and optimized cellular assays using both primary and transformed cell lines and can validate custom cell-based assays following regulatory guidelines and recommendations. Scorpius offers a diverse range of innovative platforms for any type of cell-based work that allows for multiplexing and automation for increased assay throughput and reproducibility. Our scientists will help you choose the method to optimally support your distinct cell-based assay parameters.

IMMUNOASSAYS

Immunoassays play a critical role in biopharmaceutical analysis and QC release testing. Scorpius has experience developing a wide range of methods providing quantitative, semiquantitative or qualitative detection of a variety of analytes. Immunoassay method development and the design of our method validations are tailored to meet both client and regulatory requirements. We utilize a range of analytical methodologies and are experienced in working with clients on the generation and qualification of critical immunoassay reagents.

The immunoassays available from Scorpius BioManufacturing include:

ELISA

Luminex^® Multiplex Assay

Flow Cytometry

Spectral Flow Cytometry

Cytokine ELISpot^® & Fluorospot Assays

Isoplexis Technology

qPCR MOLECULAR ASSAYS

Scorpius leverages real-time PCR, also known as quantitative PCR (qPCR), to support the pre-clinical and clinical phases of therapeutic development. Our instrumentation enables simultaneous measurement of multiple DNA amplification reactions in a single reaction vessel, making it possible to process a large number of samples simultaneously. This also enables reaction volumes at nanoliter levels, substantially reducing and therefore saving reagents and samples needed to perform the testing.

Our scientific team offers a wealth of expertise in the development, optimization and validation of complex molecular assays using conventional and quantitative PCR.

qPCR Applications:

Gene expression analysis

Drug response analysis of gene expression

Chemosensitivity profiling of cancer drugs

Mutation analysis

BIOANALYTICAL METHODS

High-Performance Liquid Chromatography (HPLC) is one of the most widely used testing techniques, from early stage development to final product characterization and QC release testing. Scorpius' team offers extensive experience in HPLC methods development, qualification and validation.

Scorpius offers Biacore™ biomolecules interaction analysis using our Biacore™ T200. This is a versatile and precise surface plasmon resonance (SPR) system that enables the analysis of a wide range of molecular interactions.

Fluorescence microscopy is a highly sensitive, specific and reliable technology for the localization of biomolecules and cells. Fluorescence imaging is reasonably gentle on the sample, which facilitates the visualization of molecules and dynamic processes in live cells. We find it is the most popular method for studying the dynamic behavior exhibited in live cell imaging.

Scorpius’ Bioanalytical Methods Capabilities

HPLC Analysis

Biacore™ Biomolecules Interaction Analysis

Fluorescent Microscopy

Looking for bioassay support and solutions?
Let’s discuss your

needs.