Process Development

Microbial Fermentation Development

Scorpius' process development staff has extensive experience optimizing microbial fermentation batch and fed-batch processes for the production of protein biologics, therapeutic enzymes and plasmid DNA at our CDMO biomanufacturing facility. We utilize an expandable, benchtop, single-use, stirred bioreactor system for statistical design of experiments (DOE) and process optimization studies.

Service Offerings

E. coli recombinant expression platforms to produce therapeutic proteins and plasmid DNA
Use of Process Excellence Six Sigma methodology (e.g., Design of Experiments) for the optimization of upstream fermentation processes
Application of QbD principles throughout development
Identification of important process parameters via FMEA analysis
Processes scalable from bench scale to 100L
Use of advanced cell culture process control strategies
Process monitoring capabilities including metabolic profile analysis
Optimization of cell lysis (mechanical vs. chemical)
Optimization of cell harvest separation process
Scale-down validation studies

Scorpius' process development staff has extensive experience optimizing microbial fermentation batch and fed-batch processes for the production of protein biologics, therapeutic enzymes and plasmid DNA. We utilize an expandable, benchtop, single-use, stirred bioreactor system for statistical design of experiments (DOE) and process optimization studies.

Capabilities

Smiling male CDMO facility worker from Scorpion Biologics Services