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US-Based Microbial CDMO

cGMP Microbial Fermentation and Manufacturing Services

Scorpius BioManufacturing is a US-based microbial fermentation CDMO offering strain development, process development, analytical development, and cGMP production of recombinant microbial proteins for vaccines and advanced therapeutics.

At Scorpius, we pride ourselves on prioritizing small programs and providing the attention and flexibility you won't find elsewhere. We dedicated ~3,200 sq. ft. of microbial process development and manufacturing cleanroom space to support your fermentation needs.

Our San Antonio-based microbial facility has two segregated Grade C cleanroom suites capable of performing both upstream and downstream processes. These spaces have capabilities and equipment for:

  • Microbial fermentation
  • Cell lysis
  • Product recovery
  • Downstream plasmid recovery
  • Protein recovery



Our Microbial CDMO Capabilities:




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Microbial Fermentation US-Based Production Process Development Vaccine Manufacturing


Scorpius' microbial cleanrooms feature dedicated air handling units that provide controlled and monitored contract manufacturing environments utilizing HEPA-filtered air for air quality classifications from EU Grade D to Grade A. The cleanrooms are designed modularly with much of the equipment on wheels for ease of configuration and reconfiguration for a variety of microbial projects. Each area is designed for maximum flexibility, including multiple electrical and process gas drops for use with microbial fermenters as well as systems for cell harvesting, mechanical lysis, downstream filtration and purification. Scorpius BioManufacturing's entire Texan facility, including the microbial fermentation cleanrooms, use American-made equipment and consumables, with many supplied mechanicals made on-site.

The controlled areas within our microbial process development and manufacturing space are purposefully designed for the unidirectional flow of personnel, raw materials, intermediates, product and waste. This design makes maintenance and cleaning easier, and the material finishes on the walls, floors and ceilings of the cleanrooms are suited to cGMP-compliant manufacturing, minimizing the potential for contamination and/or cross-contamination of manufactured products.


Our Biomanufacturing Facility:


Our dedicated microbial area features fermentation reactors with capacities of 50 and 200 L and employs single-use technology when and where possible to increase manufacturing flexibility, enhance sterility assurance, eliminate cleaning and cleaning validation, reduce capital investment, increase productivity and hasten changeovers to new product manufacturing setups.

Learn more about the capabilities at Scorpius' San Antonio facility. to see what we can do for your microbial biomanufacturing project.